Vitamin D Resources
Vitamin D3 (1,25(OH)2D3)
The sun is our most important source of vitamin D. Exposure to the sun, in moderate doses, also gives large amounts of this vitamin. The ultraviolet radiation in these sources converts 7-dihydrocholesterol to previtamin D3 in the skin. Furthermore, heat isomerization to vitamin D3 takes place, then transport to the liver and hydroxylation to calcidiol, which is transported to the kidneys and hydroxylated to the active hormone calcitriol. The vitamin D3 status of the body is supposed to be reliably imaged by calcidiol measurements. Vitamin D3 is actually considered a hormone because it made in the body by ultraviolet radiation from the sun on 7-dihydrocholesterol.

Vitamin D3 is not politically correct. It discriminates depending where you live, the further you live from the equator the less sun exposure consequently the lower your Vitamin D3 level. It discriminates against the elderly, as you age your skin loses up to 75% of its ability to make Vitamin D3. It discriminates against the obese. They have lower levels of Vitamin D3, due to the fact it is oil soluble, that it builds up in the fat tissue. It discriminates against skin color a dark complected person needs more sun exposure to produce their Vitamin D3 than a fair skinned person. It also discriminates against a person who does as they are told. It has been reported the incident of breast cancers have increased 40% in Australia due to Vitamin D3 deficiency caused by sunscreen use.

Vitamin D3 is responsible for regulating the calcium and phosphorus levels in the blood by their absorption from food and re-absorption of calcium in the kidney. It promotes bone formation and is essential in the development of strong bones. It also inhibits paraththyroid hormone secretion from the parathyroid gland. Vitamin D affects the immune system by promoting immunosuppression and anti-tumor activity.

“Osteoporosis and Low Bone Mass - Females and Males
  • Osteoporosis and low bone mass are currently estimated to be a major public health threat for almost 44 million U.S. women and men aged 50 and older.
  • The 44 million people with either osteoporosis or low bone mass represent 55 percent of the people aged 50 and older in the United States.
  • By the year 2010, it is estimated that over 52 million women and men in this same age category will be affected and, if current trends continue, the figure will climb to over 61 million by 2020. “
This information is from the National Osteoporosis Foundation. Vitamin D3 is responsible for calcium and phosphorus absorption and the mineralization of bones, Vitamin D3 levels should be routinely since osteoporosis or low bone mass affects 55% of a group or 44 million US men and women over age 50. There are two vitamin D tests -- 1,25(OH)D and 25(OH)D. 25(OH)D is the better marker of overall D status. It is this marker that is most strongly associated with overall health. The correct test is

25(OH)D, also called 25-hydroxyvitamin D

M. F. Holick, Department of Medicine, Boston University Medical Center, MA stated in Bone August 17 1995 that 1,25(OH)2D3 is a potent antiproliferative and prodifferentiation mediator. As a result, 1,25(OH)2D3 and its analogs have wide clinical application in such diverse clinical disorders as:
  • Rheumatoid and psoriatic arthritis
  • Diabetes mellitus type 1
  • Hypertension
  • Cardiac arrhythmias
  • Seizure disorders
  • Cancers of the breast, prostate, and colon
  • Some leukemias and myeloproliferative disorders
  • Chemotherapy-induced hair loss
  • Skin rejuvenation
  • Skin diseases like psoriasis and ichthyosis.
What is the dose of Vitamin D3? The correct dose will vary depending on the patient’s age, weight, skin color, geographic location and season of the year, sun exposure. Liver and kidney function also add to the complexity of dosing. Vitamin D is a fat-soluble vitamin and can be quite toxic. So don't start a program of Vitamin D3 supplementation unless you have your blood levels checked. You may choose to ignore this warning, but I am telling you in plain simple English, that while vitamin D has enormous potential for improving your health, it has nearly equal potential to worsen it, if you use it improperly. For safety purposes it is advisable to optimize your vitamin D3 levels only with the help of a physician and proper testing. Based on an article, Int J Cancer, 2004 Jan 1, it appears that a blood level of 40-60 nmol/l of 25(OH)D is optimal. Partners in Care, Inc. can prepare Vitamin D in the following dosage forms:
  • Transdermal Gels In various Strengths
  • Vitamin D3 Injectable 100,000 units/ml
  • Vitamins D2 and D3 Injectable 100,000 units/ml
  • Suppositories
  • Vitamin D2 & Vitamin D3 Capsules 100,000 units
  • Vitamin D3 Capsules 100,000 Units
John Cannell, MD in the July 2008 News letter of the Vitamin D Council answered the following question "My doctor prescribed Drisdol, 50,000 IU per week. What is it? "

His reply was "Drisdol is a prescription of 50,000 IU tablets of ergocalciferol or D2. Ergocalciferol is not vitamin D but it is similar. It is made by irradiating ergosterol, which is found in many living things, such as yeast. D2 is not normally found in humans and most studies show it does not raise 25(OH)D levels as well as human vitamin D (cholecalciferol or D3) does. However, Drisdol is a lot better than nothing. The best thing to do, if you are vitamin D deficient, and a human, is to take human vitamin D, cholecalciferol, A.K.A. vitamin D3." Vitamin D2 Is Much Less Effective than Vitamin D3

The injectables and transdermals have given the good responses, according to feedback from physicians. We have recently had a patient, with a blood level of 17 nmol/l go to 93 nmol/l using our 100,000 unit capsules of vitamin D2 & vitamin D3 in three months. However, recently we are see most precriptions are for Vitamin D3 100,000 unit capsules. These capsules a dosages from twice a week to every other week, with follow up blod levels. We can prepare the dosage form and strength ordered by your physician.Contact: Partners In Care

Potency of Vitamin D Supplementd Varies Widely From Labels 2/28/2013

Standard Partners In Care Vitamin D3 Potency Test 2/7/2013

Vitamin D3 General

Vitamin D2 Is Much Less Effective than Vitamin D3

The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918–1919 influenza pandemic in the United States

Vitamin D levels linked to Telomere Lengths and Aging

Assessment of dietary vitamin D requirements during pregnancy and lactation

Vitamin D Levels May Be Inversely Linked With Recent Upper Respiratory Tract Infection

Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's Disease

1alpha,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid-beta Clearance by Macrophages of Alzheimer's Disease Patients.

Adequate vitamin D levels may aid weight loss in obese patients

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier.

Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system.

1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease.

Vitamin D deficiency: A global perspective.

Autism and vitamin D.

Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease.

What Is the Effect of Vitamin D Deficiency During Pregnancy?

Vitamin D: A Hormone for All Seasons - How much is enough? Understanding the New Pressures

Adiposity in Relation to Vitamin D Status and Parathyroid Hormone Levels: A Population-Based Study in Older Men and Women

An update in recurrent spontaneous abortion.

Low Vitamin D Levels May Aggravate Chronic Pain

Body Fat Content and 25-Hydroxyvitamin D Levels in Healthy Women

Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes

Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.

The vitamin D epidemic and its health consequences.

1alpha,25-dihydroxy-vitamin-D3 as new immunotherapy in treatment of recurrent spontaneous abortion.

Barriers to optimizing vitamin D3 intake for the elderly.

Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994.

Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications.

Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use.

Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women.

Ultraviolet light may contribute to geographic and racial blood pressure differences.

Vitamin D and African Americans.

Vitamin D Deficiency Tied to Increased IBD Activity, Reduced Quality of Life

Vitamin D3 Cancer
Epidemiology of vitamin D insufficiency and cancer mortality.

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in normal and malignant breast tissue.

Vitamin D status and breast cancer risk.

Calcitriol in cancer treatment: From the lab to the clinic.

Epigenetic corruption of VDR signaling in malignancy.

Calcitriol in the treatment of prostate cancer.

Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.

Inhibition of angiogenesis by vitamin D-binding protein: Characterization of anti-endothelial activity of DBP-maf.

Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.

Vitamin D compounds: clinical development as cancer therapy and prevention agents.

Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D.

1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.

Vitamin D3 Asthma
Vitamin D deficiency and chronic lung disease.

Is vitamin D deficiency to blame for the asthma epidemic?

Childhood asthma may be a consequence of vitamin D deficiency.

Vitamin D, respiratory infections, and asthma.

Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children.

Childhood asthma may be a consequence of vitamin D deficiency.

Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.

Vitamin D3 Cardio Vascular Disorders

Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community

Vitamin D Deficiency: A Risk Factor for Heart Disease?

Vitamin-D deficiency now associated with increased mortality

Vitamin D: New way to treat heart failure?

Men with vitamin D deficiency may have increased risk of heart attack

Vitamin link to heart failure

Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality

Vitamin D3 Arthritis & Immune System

D-hormone and the immune system.

Hormone replacement therapy, calcium and vitamin VITAMIN D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456].

Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis.

Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe.

Vitamin D deficiency and chronic low back pain in Saudi Arabia.

1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes.

Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation.

IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis.

Vitamin D3 Diabetes

Low Serum 25-Hydroxyvitamin D Concentrations are Associated with Insulin Resistance and Obesity in Women with Polycystic Ovary Syndrome.

Vitamin D in type 1 diabetes prevention.

Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis

Feasibility of a type 1 diabetes primary prevention trial using 2000 IU vitamin D3 in infants from the general population with increased HLA-associated risk.

Protection from type 1 diabetes by vitamin D receptor haplotypes.

Monocytes from type 2 diabetic patients have a pro-inflammatory profile 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory.

Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients.

The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients.

A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report.

Vitamin D3 Children

Minority Kids Lack Enough Vitamin D

Vitamin D Levels deficient in 70 Percent of U.S. Children

Prevention and Management of Vitamin D Deficency in Children: Part I: Vitamin D Requirements

Childhood asthma may be a consequence of vitamin D deficiency.

Is vitamin D deficiency to blame for the asthma epidemic?

Childhood asthma may be a consequence of vitamin D deficiency.

Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure.

The incidence of pediatric cardiomyopathy in two regions of the United States.
Is vitamin D deficiency to blame for the asthma epidemic?

Maternal diet vs lack of exposure to sunlight as the cause of the epidemic of asthma, allergies and other autoimmune diseases.

Low Vitamin D Linked to Asthma Exacerbations

Serum vitamin D and subsequent occurrence of type 2 diabetes.

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.

Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y.

Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation.

Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis.