Below is a link showing various medications and their actions that can be combined in a transdermal gel. This allows the physician create the most effective product for their patient’s pain. The transdermals can be applied locally and along the afferent nerves (e.g. knee pain the gel is applied to the knee and along the lateral horns where the afferent nerves enter the spine). These custom gels gives the physician a tool to control the patient’s pain, while reducing or minimizing the patient’s need for systemic medications and their side effects.
If you are a pain patient, you might want to print the table off below and discuss the use of transdermal gels with your physician.
The following abstract from Pubmed reinforces the importance of the ointment mill in the preparation of quality transdermal gels.
Int J Pharm. 2008 Jun 5;357(1-2):295-304. Epub 2008 Feb 3. Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation. Puglia C, Blasi P, Rizza L, Schoubben A, Bonina F, Rossi C, Ricci M. Department of Pharmaceutical Sciences, School of Pharmacy, University of Catania, viale A. Doria 6, 95125 Catania, Italy.
Dermal therapy is still a challenge due to the difficulties in controlling the active pharmaceutical ingredient (API) fate within the skin. Recently, lipid nanoparticles have shown a great potential as vehicle for topical administration of active substances, principally owing to the possible targeting effect and controlled release in different skin strata. Ketoprofen and naproxen loaded lipid nanoparticles were prepared, using hot high pressure homogenization and ultrasonication techniques, and characterized by means of photo correlation spectroscopy and differential scanning calorimetry. Nanoparticle behavior on human skin was assessed, in vitro, to determine drug percutaneous absorption (Franz cell method) and, in vivo, to establish the active localization (tape-stripping technique) and the controlled release abilities (UVB-induced erythema model). Results demonstrated that the particles were able to reduce drug penetration increasing, simultaneously, the permeation and the accumulation in the horny layer. A prolonged anti-inflammatory effect was observed in the case of drug loaded nanoparticles with respect to the drug solution. Direct as well as indirect evidences corroborate the early reports on the usefulness of lipid nanoparticles as carriers for topical administration, stimulating new and deeper investigations in the field.
PMID: 18343059 [PubMed - indexed for MEDLINE]
The 90 second video below demonstrates the importance of one piece of equipment in the outcome of the final medication.