Suggested Patient Reading List
An informed patient is able to communicate more effectively with their physician and pharmacist.

Women's Health



The Naked Truth about Bioidentical Hormones

By: Suzanne Somers
Somers' top seller The Sexy Years introduced hundreds of thousands of readers to the advantages of bioidentical hormone therapy. Ageless offers even more recent information on the effects of these hormones on aging and health. Somers' apparently ceaseless quest for cutting-edge information has filled this book with helpful suggestions about everything from sleep problems and stress to herbs and alternative medicine. Ultimately, Ageless can be seen as an arsenal of tools to take control of the aging process, enabling you to enhance every aspect of your life.


Sexy Years: Discover the Hormone Connection:
The Secret to Fabulous Sex, Great Health, and Vitality, for Women and Men

By: Suzanne Somers
Suzanne encountered the “Seven Dwarfs of Menopause-Itchy, Bitchy, Sweaty, Sleepy, Bloated, Forgetful and All-Dried-UP”. Now she explains how she's coped with the symptoms of menopause and why she believes most women should take natural hormones during this period. Somers discusses her breast cancer surgery, along with her decision not to undergo certain follow-up treatment but instead adhere to a regimen of natural hormones. To support her case, Somers includes interviews with several physicians who specialize in natural hormones, sexual dysfunction and menopause. Her enthusiastic writing style will especially appeal to readers who have been intimidated by physicians unwilling to offer alternative treatments to menopause's often debilitating symptoms. "Finding the right doctor is difficult," she laments. "Your gynecologist may not be the right person for you at this time.... If [menopause and hormones are] not her specialty, then you have to find a doctor who 'gets it. "


The Menopause Thyroid Solution:
Overcome Menopause by Solving Your Hidden Thyroid Problems

By: Mary J. Shomon
From New York Times bestselling author and nationally recognized patient advocate Mary J. Shomon comes a groundbreaking guide to safely managing menopause through a better understanding of and better care for your thyroid.


Natural Hormone Balance for Women:
Look Younger, Feel Stronger, and Live Life with Exuberance

By: Uzzi Reiss, M.D.
A pioneering gynecologist and antiaging specialist with a successful Beverly Hills practice, Dr. Uzzi Reiss shows the way for women who want to turn back the effects of time through natural hormone therapy, but who wonder: is it safe? Does it work? Is hormone therapy right for me?

What Your Doctor May Not Tell You About Menopause (TM):
The Breakthrough Book on Natural Hormone Balance

By: John R. Lee, M.D.
This revolutionary book about hormone replacement therapy--a classic bestseller since it was first published in 1996--is now fully revised and updated, providing potentially lifesaving facts and natural alternatives to balancing hormones.

The Hormone Cure:
Reclaim Balance, Sleep, Sex Drive and Vitality Naturally with the Gottfried Protocol

By: Sara Gottfried, M.D.
All too often women are told that feeling moody, asexual, tapped out, dried up, stressed out, and sleep deprived is just a part of being female. Or they’re led to believe that the answer can be found only at the bottom of a bottle of prescription pills. Dr. Sara Gottfried, a Harvard-educated physician and nationally recognized, board-certified gynecologist, refuses to accept that being a woman means feeling overwhelmed or that popping pills is the new normal. In The Hormone Cure, she shares the unique hormone-balancing program that she has used to help thousands of women reclaim wellness, verve, and optimal health.

Natural Hormone Balance:
Achieving Optimal Hormone Health through Diet and Lifestyle Therapies
By: Suzannah Olivier
In Natural Hormone Balance, Suzannah Olivier presents a simple, comprehensive and effective all-natural program to keep hormonal problems in check using nutritional and alternative methods. Women today are questioning the wisdom of turning to artificial hormones and other techniques to alleviate their female problems. Often they are astounded to learn that women in other cultures who have different lifestyles and diets do not experience difficulties such as PMS and hot flashes. A natural, nutritional approach to balancing hormones can help eliminate PMS, menstrual pain, infertility, mood swings, irregular cycles, menopausal symptoms, osteoporosis, endometriosis, fibroids, ovarian cysts, breast lumps and other problems. Now, all the nutritional advice women need to beat hormonal problems is brought together in Natural Hormone Balance, giving them control over their bodies in a way never thought possible before.


Dr. John Lee's Hormone Balance Made Simple:
The Essential How-to Guide to Symptoms, Dosage, Timing, and More

By: John Lee, M.D. & Virginia Hopkins
The authors of the classic books on menopause and premenopause bring women an easy-to-use guide on balancing hormone levels safely and naturally.


Bioidentical Hormones Made Easy!
By: Y.L. Wright, M.A.
Learn about bioidentical hormone replacement therapy (BHRT) in a quick and easy book. Learn about the history of hormone replacement (HRT) and discover why all HRT is feared, even bioidentical hormones. Learn how to find a doctor who will help you and not hurt you. Explore all of your BHRT options, learning how to replace your hormones safely, so that you can prevent heart disease, cancer, and all other diseases of aging.

The Savvy Woman's Guide to Testosterone:
How to Revitalize Your Sexuality, Strength and Stamina

By: Elizabeth Lee Vliet, M.D.
Testosterone is as natural to women as estrogen. It is not just a man's hormone. From a woman's teens until menopause, her body makes more testosterone than estrogen! Testosterone is crucial to a woman's health and well-being. Loss of testosterone can cause loss of sex drive and sexual sensation, marked fatigue, low energy, hair loss, decreased stamina, loss of height, weakness, decreased metabolism and other symptoms. Even though new testosterone therapy options for women have yet to reach the consumer market - Dr. Vliet guides you through the treatment options currently available and taches women how to successfully apply them. Much as Viagra revolutionized the treatment of erectile dysfunction in men. it's now the women's turn. This book provides reliable, cutting-edge medical information, important now to overcome stigma and negative myths about testosterone. Dr. Vliet teaches women to avoid risks of improper dosing using new treatment options with bioidentical testosterone. This book will help women learn ways to restore libido, improve muscle strength, build healthy bone, and maintain normal energy levels.

        Ovarian-Adrenal-Thyroid Axis Imbalance:
Why Your Thyroid Medications May Not Be Working (Dr. Lam's Adrenal Recovery Series)

By: Michael Lam, M.D. & Dorine Lam, R.D.
The body’s hormonal organs are closely tied together through various axes. Though lesser known than the HPA (hypothalmic-pituitary-adrenal) axis, the ovarian-adrenal-thyroid (OAT) hormonal axis is extremely important. When the OAT axis is disrupted, there is an imbalance of hormones that leads to symptoms of estrogen dominance, low energy, and hypothyroidism. Each component of the OAT axis affects the others. Imbalance of one will worsen the other and vice versa. Dr. Lam explains the clinical significance of Ovarian-Adrenal-Thyroid Axis Imbalance in this publication.

Depression and Your Thyroid:
What You Need to Know

By: Peter J. Bieling, PhD & Gary S. Ross, MD
Thyroid and psychological health are often linked. If you develop a thyroid condition, you may also become depressed. This depression can lead to more problems with your thyroid which, in turn, can lead to further depression-a vicious cycle that is difficult to treat unless the problem is addressed on several levels. Now you can determine whether the depression you're feeling may be connected to a thyroid problem. The authors of this book, a medical doctor and a psychologist, guide you through the facts about thyroid disorders, what the thyroid hormone does, and how it functions in relation to your psychological well-being. You'll learn a number of diet and lifestyle changes you can combine with conventional medical treatment to help correct a thyroid condition. You'll also learn psychological strategies you can use to overcome the depression that can result from a thyroid condition-thought monitoring, stress reduction, relationship enhancement, and more.

Feeling Fat, Fuzzy, or Frazzled?:
A 3-Step Program to: Restore Thyroid, Adrenal, and Reproductive Balance, Beat Hormone Havoc, and Feel Better Fast!

By: Richard L. Shames & Karilee Shames
For the 33 million Americans who feel sluggish, spacey, and stressed out daily, Feeling Fat, Fuzzy, or Frazzled? is the first book to address the delicate balance among the thyroid, adrenal, and reproductive glands—which can make the day-to-day difference between feeling awful and feeling good. Long-term, if left untreated, this imbalance can cause heart disease, diabetes, arthritis, infertility, and severe menopause. Authored by an expert physician/nurse team, the book offers readers: an innovative program to identify their particular hormone-related metabolic disorder; a “5-day jumpstart program” to help alleviate weight gain, low energy, or frayed nerves fast; and a long-term plan to achieve optimal health.

        Thyroid For Dummies
By: Alan L. Rubin, MD
If you or a loved one has been diagnosed with a thyroid condition, you’ve probably found out at least a little about this mysterious gland—just enough to want to look for answers to the many questions that keep popping up in your mind. What causes this condition? How is it treated? What can you do to get healthy again? Thyroid for Dummies, 2nd Edition gives you the detailed information you're looking for on new methods for detecting thyroid disease in both adults and children, alternative treatments, pros and cons of powerful new drugs now on the market, advice for managing the disease through changes in exercise and diet, and much more.

         Overcoming Thyroid Disorders:
By: David Brownstein
Dr. Brownstein's Book, Overcoming Thyroid Disorders (2nd Edition) shows how a holistic treatment program can effectively treat: Hypothyroidism, Graves' Disease, Hashimoto's Disease, Fibromyalgia, Chronic Fatigue Syndrome, Arthritis And Much More! Overcoming Thyroid Disorders provides information on safe and effective natural therapies to help the body heal itself. Dr. Brownstein provides over 30 actual case studies of his success in treating thyroid disorders. Overcoming Thyroid Disorders contains information on: Natural Thyroid Hormone, Bioidentical Natural Hormones, Diet Vitamins and Minerals Important for Thyroid Function Detoxification And Much More!

         Why Isn't My Brain Working?:
A Revolutionary Understanding of Brain Decline and Effective Strategies to Recover Your Brain's Health

By: Datis Kharrazian, MD
Losing your memory? Can't focus or concentrate? Do you have brain fog or tire easily? Have you lost your zest for life or motivation? Do people tell you this is all a normal part of aging? If so, your brain may be growing old too fast, or degenerating. Modern diets, a stressful lifestyle, and environmental toxins all take their toll on the brain. This doesn't just happen to seniors-brain disorders and degeneration are on the rise for young and old alike. The good news is the brain is extremely adaptable and wants to get well. You simply have to know how to feed and care for your brain. How do you know if your brain isn't working? See if some of these signs and symptoms of brain degeneration apply to you: Memory loss • brain fog • depression • anxiety • difficulty learning • lack of motivation, drive, or passion • tire easily • poor focus and concentration • fatigue in response to certain chemicals or foods Brain degeneration affects millions of Americans of all ages. The destruction sets in years or even decades before Alzheimer's, Parkinson's, multiple sclerosis, or other serious neurological diseases can be diagnosed. Learn how to spot brain degeneration and stop it before it's too late. Why Isn't My Brain Working? will teach you strategies to save and improve brain function. You will learn how simple diet and lifestyle changes and nutritional therapy can profoundly impact your brain health and thus the quality of your life. Don't waste another day wondering why your brain is not working. Learn what you can and should do about it. Why Isn't My Brain Working? harnesses cutting-edge scientific research for safe, simple, and truly effective solutions to declining brain function.

Thyroid Mind Power:
The Proven Cure for Hormone-Related Depression, Anxiety, and Memory Loss

By: Richard Shames, MD & Karilee Shames, PhD, RN
One in ten Americans has some degree of thyroid imbalance, and even mild imbalances can cause mental and emotional symptoms. This groundbreaking look pinpoints the connection between thyroid imbalance and conditions such as depression, anxiety, irritability, and more, offering hope for millions who are suffering from improper diagnosis and medication. The authors of the best-selling Thyroid Power, Richard Shames, MD, and his wife, Karilee, a holistic nurse, have been treating patients with this program for over 25 years. Their program shows readers how to: 1)Uncover a hidden cause for mental symptoms; 2)Discover the best treatments for each Mind type, such as moody, edgy, foggy, or sleepy; 3)Obtain the most effective cure, with recommendations for common prescription drugs (not antidepressants), natural remedies, vitamins, and supplements. Armed with the Shameses’ advice and recommendations, readers will be able to participate more actively in their health care and find relief for these common and widespread conditions.

Recovering with T3:
My Journey from Hypothyroidism to Good Health Using the T3 Thyroid Hormone

By: Paul Robinson
There is growing awareness that some people do not appear to recover their former health using the standard levothyroxine (T4) thyroid medication and may remain with many of the symptoms of hypothyroidism that they first went to their doctor with. The author describes his struggle with hypothyroidism and how eventually he regained his health using a medication called liothyronine sodium, which is a synthetic equivalent of the thyroid hormone T3. The use of T3 finally enabled the author to make a complete recovery, although there were many lessons that he needed to learn about T3 in order to regain his health. This book covers a vast amount of technical and practical information relating to T3 medication and details how the author applied this information in order to get well. The book has a foreword by Dr. John C. Lowe, who has this to say about the book: "Paul Robinson has written a book chock-full of information on T3 that is vitally important to many people. I believe that reading 'Recovering with T3 My Journey from Hypothyroidism to Good Health Using the T3 Thyroid Hormone' will be a splendid experience for thousands of people, whether clinicians, patients, patient advocates, or patients' loved ones." 'Recovering with T3' is quite simply essential reading for any patient and their doctor if they are considering the use of the T3 thyroid hormone. This revised edition contains many enhancements and improvements over the original Recovering with T3 book released at the end of 2011. Enhancements were made due to some valuable patient feedback and the experience of thousands of thyroid patients with the T3 dosage management process and the highly effective circadian T3 method (CT3M).

         Hashimoto's Thyroiditis:
Lifestyle Interventions for Finding and Treating the Root Cause

By: Izabella Wentz, PharmD & Marta Nowosadzka, MD
What’s Really Going on in Hashimoto’s? Hashimoto's is more than just hypothyroidism. Most patients with Hashimoto's will present with acid reflux, nutrient deficiencies, anemia, intestinal permeability, food sensitivities, gum disorders and hypoglycemia in addition to the “typical” hypothyroid symptoms such as weight gain, cold intolerance, hair loss, fatigue and constipation. The body becomes stuck in a vicious cycle of immune system overload, adrenal insufficiency, gut dysbiosis, impaired digestion, inflammation, and thyroid hormone release abnormalities. This cycle is self-sustaining and will continue causing more and more symptoms until an external factor intervenes and breaks the cycle apart. The lifestyle interventions discussed in this book aim to dismantle the vicious cycle piece by piece. We start with the simplest modifications, by removing triggers, and follow with repairing the other broken systems to restore equilibrium, allowing the body to rebuild itself.

Men's Health
         Hormone Balance for Men
By: John R. Lee, MD
What your doctor may not tell you about prostate health and natural hormone supplementation. This booklet is the original and thought-provoking work by John R. Lee, M.D. about men's hormones, how men can use natural hormones for optimal health, causes of prostate cancer and more. A quick read, yet loaded with useful information and suprising insights about male hormones.

A Man's Guide

By: Nelson Vergel
Are you experiencing fatigue and low or no sex drive? Do you seem to have less mental focus? Do you have less tolerance to stress and feel down? Is your body getting softer while you are gaining fat? Have you been exercising for months or years without improvements in your body? You do not have the problems mentioned but you want to how to keep your testosterone within healthy ranges? Then, this book may be for you. You may be one of the 13 million men in the United States that are suffering from testosterone deficiency and who are suffering needlessly by not knowing it. This book will explain in clear and practical language the symptoms and treatments of testosterone deficiency to help determine if you are a good candidate for this therapy. Testosterone replacement therapy (TRT) can dramatically boost sex drive and function, strength, energy levels, mood, mental focus, and lean body mass while decreasing fat in men with testosterone deficiency syndrome (hypogonadism).

         Man 2.0 Engineering the Alpha:
A Real World Guide to an Unreal Life: Build More Muscle. Burn More Fat. Have More Sex

By John Romaniello & Adam Bornstein
Every man has the potential for a great body, insane sex, and an unreal life (Seriously). Want to lose body fat? That's easy—you can drop 20 pounds in 6 weeks. Want bigger muscles? Done. A 50-pound increase to your bench press, coming right up. Want to be smarter? Not a problem—the strategies in this book have been proven to increase brain function. Want an awesome sex life? Yeah, there's a fix for that, too—increased libido and improved performance are just weeks away. You were born to achieve greatness, to be a man. But somewhere along the way you started to live an ordinary life. Fitness experts John Romaniello and Adam Bornstein developed a system that targets hormone optimization; their approach is specifically designed to transform you into the Alpha you were always meant to be. Strong. Confident. Powerful. Based on cutting-edge, scientifically validated methods known only to the fitness elite, Man 2.0 provides a step-by-step road map to regaining your health, looking your best, supercharging your sex life—even reversing the aging process. The systems in this book have changed the lives of countless men who've worked with Romaniello and Bornstein. In this book, you will discover: answers to all the questions you have about training and nutrition—and even ones you haven't thought of yet, an easy-to-understand plan designed to work with your body, not against it, to burn fat, and build dense, rock-hard muscle and a comprehensive nutrition program, fully customized for Alphas, complete with meal plans.

         The Testosterone Syndrome:
The Critical Factor for Energy, Health, and Sexuality - Reversing the Male Menopause

By: Eugene, M.D. Shippen & William Fryer
Testosterone therapy can improve the overall health and feeling of well-being of aging men, improving sex drive, mental functions, and energy levels and reducing the risk of cardiovascular disease.—Library Journal

         The Testosterone Solution:
Increase Your Energy and Vigor with Male Hormone Therapy

By: Aubrey Hill
Younger men take their good health and virility for granted. As time goes on, though, we don't always feel as strong, as sharp, as confident as we used to. Our sexual prowess — even our interest in sex — declines. It doesn't have to be that way. In this groundbreaking book, Dr. Aubrey Hill explains how men can recapture their youthful vigor through testosterone replacement therapy. As we age, our body's production of testosterone declines. Now there are safe and effective ways to boost our natural supplies. The positive impact is exciting — and almost immediate! Millions of women have reinvigorated their lives with estrogen, the natural female hormone. Men can do the same with testosterone, the natural male hormone.

         The Miracle of Bio-Identical Hormones, 2nd edition
By: Michael E. Platt, MD
The 2nd edition of Michael E. Platt, M.D.'s ground-breaking health book, The Miracle of Bio-Identical Hormones, How I Lost My... fatigue, hot flashes, ADHD, ADD, fibromyalgia, PMS, osteoporosis, weight, sexual dysfunction, anger, migraines., provides many answers to common medical problems, and explains how balancing your hormones can contribute to your well-being and your long-term health. Outstanding praise has been received for this intelligently written book by wellness colleagues, book reviewers, and patients from around the world for its new ideas and unique perspective on hormones and preventive medicine.Dr. Platt explores how natural (non-synthetic) bio-identical hormones can have the power to heal many maladies often considered "incurable." "This is the most important health book published this year, or any year for that matter. It's an easy, fascinating, highly-informative, even life-changing read," states Barbara Morris, compounding pharmacist and author of Put Old On Hold. The book is also considered an excellent primer for compounding pharmacists and the wellness community.

         The Andropause Mystery:
Unraveling Truths About the Male Menopause

By: Robert S. Tan, MD
Dr. Robert Tan draws upon his many years of treating older men during their Andropausal years to share his personal research findings (superbly illustrated with case histories) to define the Andropausal biological milestone for the aging male; describe the evolving physical, sexual, psychosocial and mental challenges encountered; explain the role of hormones and supplements relevant to the Andropause phenomenon; and offers unique perspectives on memory loss, erectile dysfunction and sexuality during the Andropause. Written with a completely reader friendly and accessible text, The Andropause Mystery is highly recommended to both medical professionals and the interested non-specialist general reader.

How To Cope with Male Menopause -
The Andropause Mystery Revealed (HRT - Hormone Replacement Therapy)

By: Treat Preston, MD
How To Cope with Male Menopause - The Andropause Mystery Revealed is all about the controversial subject of male menopause or “andropause”. It discusses in detail what is male menopause, male menopause symptoms, male menopause treatment, andropause, HRT or hormone replacement therapy, and hormone imbalance. Women may not be the only ones who suffer the effects of changing hormones. Some doctors are noticing that men are reporting some of the same symptoms that women experience in perimenopause and menopause. The medical community is debating whether or not men really do go through a well-defined menopause. Doctors say that men receiving hormone therapy with testosterone have reported relief of some of the symptoms associated with so-called male menopause. Because men do not go through a well-defined period referred to as menopause, some doctors refer to this problem as androgen (testosterone) decline in the aging male -- or what some people call low testosterone. Men do experience a decline in the production of the male hormone testosterone with aging, but this also occurs with conditions such as diabetes. Get all of the facts in “How To Cope with Male Menopause - The Andropause Mystery Revealed”!

Secrets about Bioidentical Hormones to Lose Fat and Prevent Cancer, Heart Disease, Menopause, and Andropause, by Optimizing Adrenals, Thyroid, Estrogen, Progesterone, Testosterone, and Growth Hormone!
By: Y. L. Wright, MA
Feel great, look great, lose weight, and have better sex! Discover groundbreaking scientific secrets about bioidentical hormones unknown to most people, including most physicians. Use the guidance of hundreds of anti-aging physicians and researchers to minimize and reverse aging. Change your life and feel young again with the Wiley protocol. Mimic the cyclic monthly hormones of a healthy 20-year old. Learn how hormonal and metabolic disturbances make you sick and fat. Understand imbalances in insulin, adrenal, thyroid, growth hormone, and sex hormones. Find out how hormones become deficient and unbalanced, especially during menopause and andropause. Replace missing hormones while taking precautions to minimize your cancer risk. Use this book to work with a forward-thinking, knowledgeable physician in your area who will prescribe ALL of the bioidentical hormones that you need in the dosages and rhythms needed. No other book available presents a discussion of hormonal optimization in such a comprehensive and integrated manner.

Borderline Man:
A Story of Andropause and Awakening

By: geMcknight
There are all sorts of commercials on TV these days mentioning the symptoms of Low T (low testosterone or Andropause): lack of energy, low sex drive, weight gain and a host of other implications shared by handsome, yet sad looking, gentlemen who no longer enjoy life like they once did. The sad part is that millions of men suffer from the side effects of not having enough of this vital hormone. Their lives slowly (or rapidly), fall apart and they don't know why...and if the hormones are low enough, they may not have enough energy to care or do anything about it. In Borderline Man, the author shares the true and painful story of what it was like to sit at the edge of life, not caring what happens until it is too late to do anything about it. He tells the heart-wrenching story of having mumps at 17 after puberty and how that incident led to a life lived as a Borderline Man. He shares openly the pain of his marriage crumbling, his weight gain, his struggle to understand why he didn't know what was happening sooner, the anger at medical professionals for not checking his testosterone levels sooner. Women, please read this book and see if your loved one is suffering from any of the symptoms of low testosterone. The behaviors that drive you bonkers may very well be part of those symptoms and you could be amazed to find that under the sadness, "laziness", exhaustion and disinterest is the man you once loved more than you knew possible.

What Every Man and Wife Should Know: A Guide To Treatment For Men

By: Allan Wagner
Is it real, does it really exist? There are many persons who are doubtful that there is in fact a male version to the female menopause. This is largely due to the fact that men can reproduce even up into their old age, while woman cannot do so when they get to a certain age. However, even though there are persons who do not believe that it does exist; it is in fact a reality. Those men who usually fall between the ages of about forty to forty five and are going through andropause are those who are experiencing issues having to do with a significant decrease in their levels of testosterone. This diminished level of testosterone causes a number of physical, social, emotional, psychological, mental and even sexual issues in men that are andropausal. These men tend to sometimes do things that lead people to think that they are going through what is popularly known as a midlife crisis. This is so due to the fact that men who are going through andropause tend to be re-evaluating their lives and their accomplishments and some wanting to change who they are and what they are doing, may end up doing some of the things that they wanted to do when they were younger but did not get to do. However many of them just now want to be closer to their family members and friends and not to keep doing what they used to do; hence the reevaluation of their priorities and their accomplishments. The main treatment for andropausal men is testosterone replacement therapy.

Preterm Delivery
Progestogens for Prevention of Preterm Birth:
Comparative Effectiveness Review Number 74

By: U. S. Department of Health and Human Services & Agency for Healthcare Research and Quality
Birth before completion of 37 weeks of pregnancy is considered preterm. These early births are associated with more than 85 % of all perinatal morbidity and mortality and are the leading cause of infant mortality and long-term disability. Each year in the U.S. more than 475,000 infants are born preterm representing 12.5 % of live births. Efforts to reduce preterm birth have been largely unsuccessful, with a 20 % relative increase since 1990 in the proportion of births in the U.S. that are preterm. Morbidity and mortality associated with preterm birth represent untold distress for families, as well as significant costs to patients, health care systems, and payers. Average neonatal care costs are estimated to be $17,300 greater for preterm infants relative to term infants, amounting to more than $8.6 billion of annual medical spending in the U.S. The ultimate goal in preventing preterm birth is to eliminate the risks of neonatal complications and death and to ensure normal development. In the last decade, accumulating evidence from randomized clinical trials (RCTs) has led professional organizations and an Institute of Medicine working group to endorse the use of progestogens for women with prior spontaneous preterm birth. However, these groups also note interest in assessing long-term safety because the legacy of diethylstilbestrol suggests caution and extended followup of mothers and infants after hormone use in pregnancy. Unresolved issues about choice of progestogen, optimal route of drug delivery, and other candidate high-risk populations for treatment remain.